Thesis on midazolam

Uses Uses Midazolam is used before surgery or a procedure. It helps to cause drowsiness, decrease anxietyand to decrease your memory of the surgery or procedure. This medication may also be used to help with anesthesia or to sedate people who need a tube or machine to help with breathing. Midazolam works by calming the brain and nerves.

Thesis on midazolam

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Thesis on midazolam

Various adjuvants have been used with local anesthetics in spinal anesthesia to avoid intraoperative visceral and somatic pain and to provide prolonged postoperative analgesia. The aim of this study was to evaluate the onset and duration of sensory and motor block, hemodynamic effect, postoperative analgesia, and adverse effects of dexmedetomidine or fentanyl given intrathecally with hyperbaric 0.

Sixty patients classified in American Society of Anesthesiologists classes I and II scheduled for lower abdominal surgeries were studied.

Patients were randomly allocated to receive either Patients in dexmedetomidine group D had a significantly longer sensory and motor block time than patients in fentanyl group F. Intrathecal dexmedetomidine is associated with prolonged motor and sensory block, hemodynamic stability, and reduced demand for rescue analgesics in 24 h as compared to fentanyl.

Bupivacaine, dexmedetomidine, fentanyl, spinal anaesthesia Introduction Spinal anesthesia is the most commonly used technique for lower abdominal surgeries as it is very economical and easy to administer. However, postoperative pain control is a major problem because spinal anesthesia using only local anesthetics is associated with relatively short duration of action, and thus early analgesic intervention is needed in the postoperative period.

A number of adjuvants, such as clonidine and midazolam, and others have been studied to prolong the effect of spinal anesthesia.


Written informed consent was obtained from all patients. All patients received diazepam 0. They were monitored with automated noninvasive blood pressure, pulse oximetry, and electrocardiogram. Patients were randomly divided into the following groups: Group D—to receive 2. Intrathecal injection was given over approximately 10—15 s.

Immediately after completion of the injection patients were made to lie supine. The incidence of adverse effects, such as nausea, vomiting, shivering, pruritus, respiratory depression, sedation, and hypotension were recorded.

Sensory testing was assessed by loss of pinprick sensation to 23G hypodermic needle and dermatomes levels were tested every 2 min until the highest level had stabilized by consecutive tests.

On achieving T7 sensory blockade level, surgery was allowed. Testing was then conducted every 10 min until the point of two segment regression of the block was observed. Further testing was performed at min intervals until the recovery of S2 dermatome.

The surgeon, patient, and the observing anesthesiologist were blinded to the patient group.

Thesis on midazolam

Data regarding the highest dermatome level of sensory blockade, the time to reach this level from the time of injection, time to S1 level sensory regression, time to urination, and incidence of side effects were recorded. Sedation was assessed by a modified Ramsay sedation scale. Modified Ramsay sedation scale.In the first part of this thesis, I examined the structure-function relationship of the benzodiazepine binding site on GABAA receptors.

Mutations were created in loop A, loop B, and loop C of the benzodiazepine site across the six different α subunits. Effects were measured using midazolam.

Results from whole-cell patch clamp recording of. Midazolam is a short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia.

Midazolam, marketed under the trade name Versed, among others, is a medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation. It works by inducing sleepiness, decreasing anxiety, and causing . Find patient medical information for Midazolam Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

The children in the midazolam group required less postoperative analgesia and thus midazolam was considered superior to clonidine as an oral preanesthetic medication (Fazi et al., ). Although this trial was limited to patients receiving tonsillectomies, it is indicative of the need for future research on standardizing care practices on.

Effectiveness and Complications of Sedation Regimens Used for Pediatric Dental Patients THESIS Presented in Partial Fulfillment of the Requirements for the Degree Master of Science in midazolam was the regimen most often rated as either effective or somewhat effective.

Midazolam Injection : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD